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Većina droga povećava količinu ovih neurotransmitera vršeći njihovo djelovanje i oni mogu pružiti osjećaj zadovoljstva, što je euforija.Kokain se dobiva iz lista koke i više od tisuću godina starosjedioci su listing žvakali zbog zadovoljstva i energije. Ovi stimulativni učinci učinili su biljku koke cijenjenom u ovim zajednicama.[one h